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Horm Metab Res 1972; 4(2): 119-121
DOI: 10.1055/s-0028-1094081
DOI: 10.1055/s-0028-1094081
Originals
© Georg Thieme Verlag KG Stuttgart · New York
Inhibition of the Estrogenic Activity of Triphenylethylene by 6-Aminochrysene and Other Inducers of Drug-Metabolizing Enzymes
Further Information
Publication History
Publication Date:
07 January 2009 (online)
Abstract
It was found that 6-Aminochrysene significantly reduces the estrogenic activity of triphenylethylene; this effort is most probably connected with the inducing activity of 6-aminochrysene towards microsomal drug-metabolizing enzymes, as a similar reducing effect was displayed by benz[a]anthracene and, to a lesser extent, by 13H-dibenzo[a,g]fluorene, both of which are also potent enzyme inducers.
Key words
6-Aminochrysene - Benz[a]anthracene - Triphenylethylene - Estrogenic Activity - Drug Metabolizing Enzymes